Profiles
Tyler Bold
Graduate Student, Molecular Oncology and Immunology
Univ. Illinois at Urbana-Champaign
Email:
Faculty Mentor: Joel Ernst, M.D.
Microbial pathogens induce complex immune responses by the hosts they infect. A better understanding of these responses is an essential prerequisite for the development of new vaccines and immunomodulatory therapies to prevent and treat infectious diseases. I study the initiation and maintenance of adaptive immune responses against the highly successful human pathogen, Mycobacterium tuberculosis. Raised in North Dakota and educated in Illinois, I now call Brooklyn home.
Thesis
Initiation and maintenance of adaptive immunity to mycobacterium tuberculosis
Selected Publications
Bold TD, Ernst JD. Who benefits from granulomas, mycobacteria or host? Cell. 2009 Jan 9;136(1):17-9. Cited in Pubmed; PMID 19135882. doi: 10.1016/j.cell.2008.12.032.
Jayathilaka K, Sheridan SD, Bold TD, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53. Epub 2008 Oct 7. Cited in Pubmed; PMID 18840682. doi: 10.1073/pnas.0808046105. PMCID: PMC2572930.
Zayas RM*, Bold TD*, Newmark PA. Spliced-leader trans-splicing in freshwater planarians. Mol Biol Evol. 2005 Oct;22(10):2048-54. Epub 2005 Jun 22. Cited in Pubmed; PMID 15972844. doi: 10.1093/molbev/msi200.
