Steven Quatela, M.D., Ph.D.
Current Position:
PGY-1 Resident in Pediatrics, NewYork-Presbyterian Hospital/Weill Cornell Medical Center, New York.
Graduate: 2009, Molecular Pharmacology and Signal Transduction
William Randolph Hearst Foundation Fellow
(BS Biology, with area of concentration in Biochemistry, Haverford College)
Faculty Mentor: Mark Philips, M.D.
After many long nights (and early mornings!) in the confocal microscope room, Steve completed his Ph.D. in the Philips Lab studying how the phosphorylation of K-Ras can trigger cellular apoptosis. Steve is looking forward to making kids smile during his pediatric residency and, one day, hopes to have a fulfilling life as a pediatric oncologist.
Thesis
PKC regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-XL on Mitochondria and Induces Apoptosis
Research Interests
Cell Signaling; Oncogenesis
Selected Publications
Quinlan MP,
Quatela SE, Philips MR, Settleman J. Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol. 2008 Apr;28(8):2008 Feb 11. Cited in Pubmed; PMID 18268007. doi:
10.1128/MCB.01661-07. PMCID: PMC2293097.
Quatela SE,
Sung PJ,
Ahearn IM,
Bivona TG, Philips, MR. Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis. Methods Enzymol. 2008;439:87-102. Epub 2008 Mar 26. Cited in Pubmed; PMID 18374158. doi:
10.1016/S0076-6879(07)00407-7. PMCID: PMC2293097.
Beigneux AP, Vergnes L, Qiao X,
Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 2006 Apr 1;47(4):734-44. Epub 2006 Jan 31. Cited in Pubmed; PMID 16449762. doi:
10.1194/jlr.M500556-JLR200.
Quatela SE, Philips MR. Ras signaling on the Golgi. Curr Opin Cell Biol. 2006 Apr;18(2):162-7. Epub 2006 Feb 20. Cited in Pubmed; PMID 16488589. doi:
10.1016/j.ceb.2006.02.004.
Beigneux AP, Vergnes L, Qiao X,
Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips MR, Reue K, Young SG. Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 2006 Apr;47(4):734-44. Epub 2006 Jan 25. Cited in Pubmed; PMID 16436371. doi:
10.1194/jlr.M500553-JLR200.
Beigneux AP, Vergnes L, Qiao X,
Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. J Lipid Res. 2006 Apr;47(4):734-44. Epub 2006 Jan 31. Cited in Pubmed; PMID 16449762. doi:
10.1194/jlr.M500556-JLR200.
Bivona TG,
Quatela SE, Bodemann BO,
Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Pérez de Castro I, Li C, Thompson CB, Cox AD, Philips MR. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell. 2006 Feb 17;21(4):481-93. Cited in Pubmed; PMID 16483930. doi:
10.1016/j.molcel.2006.01.012.
Bivona TG,
Quatela S, Philips MR. Analysis of Ras activation in living cells with GFP-RBD. Methods Enzymol. 2006;407:128-43. Cited in Pubmed; PMID 16757320. doi:
10.1016/S0076-6879(05)07012-6.
Additional Information
Philips Lab
