Steve Braunstein, M.D., Ph.D.
Current Position:
Resident in Preliminary Medicine, Brigham & Women’s Hospital, Boston; PGY-2 Radiation Oncology, University of California, San Francisco.
Graduate: 2009, Microbiology
AΩA Medical Honor Society
(BS Chemistry; BA Psychology, CUNY Brooklyn College)
Faculty Mentor: Robert Schneider, Ph.D.
I will be a resident in Preliminary Medicine, Brigham & Women's Hospital, Boston, with a PGY-2 in Radiation Oncology, University of California, San Francisco. My research interests include the plethora of pathways influencing alterations in mechanisms of translational control which ultimately contribute to pathogenesis in cancer.
Thesis
Alterations in Translational Control Pathways in Breast Cancer
Research Interests
Initiation of protein synthesis; Elongation of protein synthesis; Termination of protein synthesis; Cell cycle; DNA repair pathways; Cell death/apoptosis/autophagy
Selected Publications
Ramírez-Valle F, Braunstein S, Narasimhan M, Schneider RJ. Mitosis-specific Modification of raptor Increases mTORC1 Activity During G2/M. Curr Bio. Forthcoming 2009.
Matsumura S, Wang B, Kawashima N,
Braunstein S, Badura M, Cameron TO, Babb JS, Schneider RJ, Formenti SC, Dustin ML, Demaria S.
Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008 Sep 1;181(5):3099-107. Cited in Pubmed; PMID 18713980. PMCID: PMC2587101.
Ramírez-Valle F,
Braunstein S, Zavadil J, Formenti SC, Schneider RJ. eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J Cell Biol. 2008 Apr 21;181(2):293-307. Cited in Pubmed; PMID 18426977. doi:
10.1083/jcb.200710215. PMCID: PMC2315676.
Braunstein S, Formenti SC, Schneider RJ. Acquisition of stable inducible up-regulation of nuclear factor-kappaB by tumor necrosis factor exposure confers increased radiation resistance without increased transformation in breast cancer cells. Mol Cancer Res. 2008 Jan;6(1):78-88. Cited in Pubmed; PMID 18234964. doi:
10.1158/1541-7786.MCR-07-0339.
Braunstein S, Karpisheva K, Pola C, Goldberg J, Hochman T, Yee H, Cangiarella J, Arju R, Formenti SC, Schneider RJ. A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell. 2007 Nov 9;28(3):501-12. Cited in Pubmed; PMID 17996713. doi:
10.1016/j.molcel.2007.10.019.
Oxelmark E, Roth JM, Brooks PC,
Braunstein SE, Schneider RJ, Garabedian MJ. The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol. 2006 Jul;26(14):5205-13. Cited in Pubmed; PMID 16809759. doi:
10.1128/MCB.00009-06.
Connolly E,
Braunstein S, Formenti S, Schneider RJ. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol. 2006 May;26(10):3955-65. Cited in Pubmed; PMID 16648488. doi:
10.1128/MCB.26.10.3955-3965.2006. PMCID: PMC1489005.
Kim SS, Zhang RG,
Braunstein SE, Joachimiak A, Cvekl A, Hegde RS. Structure of the retinal determination protein Dachshund reveals a DNA binding motif. Structure. 2002 Jun;10(6):787-95. Cited in Pubmed; PMID 12057194. doi:
10.1016/S0969-2126(02)00769-4.
Medical Specialization
Radiation Oncology
Additional Information
Schneider Lab
