Profiles

Shella Saint Fleur, Ph.D.

Fellow in Clerkship, Molecular Oncology and Immunology
Pathology Departmental Training Grant
BS Biology, Brooklyn College
Email:
Faculty Mentor: Hodaka Fujii, M.D., Ph.D.

Shella’s interest in Medicine dates back to childhood experiences and wanting to make a difference in the lives of people of the small town in Haiti where she grew up. But it was only after starting college in the U.S. and having experienced the laboratory that she realized she has the mind of a scientist. What better way to combine her two interests than to become a physician-scientist? She is fascinated by the immune system. She also enjoys time with her family and her church community.

Thesis

Cyclon, a novel cytokine-induced protein regulates Fas-mediated T cell homeostasis

Research Interests

Immune system regulation and function; Cytokine signaling; Apoptosis; Cancer immunity

Selected Publications

Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H. Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon. Blood. 2009 Aug 13;114(7):1355-65. Epub 2009 Jun 15. Cited in Pubmed; PMID 19528538. doi: 10.1182/blood-2008-11-189118. PMCID: PMC2727414 [Available on 2010/08/13].

Saint Fleur S, Fujii H. Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system. Cytokine. 2008 Mar;41(3):187-97. Epub 2008 Jan 18. Cited in Pubmed; PMID 18203617. doi: 10.1016/j.cyto.2007.11.023. PMCID: PMC2289906.

Hoshino A, Saint Fleur S, Fujii H. Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain. Biochem Biophys Res Commun. 2006 Aug 4;346(3):1062-6. Epub 2006 Jun 12. Cited in Pubmed; PMID 16782051. doi: 10.1016/j.bbrc.2006.06.026. PMCID: PMC1861812.