Profiles

Serre-Yu Wong, Ph.D.

Fellow in Clerkship, Molecular Oncology and Immunology
MOI Training Grant
AB Biochemical Sciences, Harvard University
Email:
Faculty Mentor: David B. Roth, M.D., Ph.D.

In the Roth lab, I am studying how altered DNA sequence recognition by a mutant V(D)J recombinase affects the diversity of the T cell receptor and immunglobulin repertoires and its implications for the pathogenesis of Omenn Syndrome, a genetic disease characterized by both immune deficiency and autoimmunity. Outside of the lab, I enjoy road cycling, trying my hand at improv comedy with the medical school group Humerus, and eating in NYC.

Thesis

Coding Sequence sensitivity of the RAG complex: mechanisms and implications for V(D)J recombination and antigen receptor diversity

Research Interests

Lymphocyte receptor diversity; V(D)J recombination; Omenn Syndrome; Immunodeficiency; Autoimmunity

Selected Publications

Wong SY*, Lu CP*, Roth DB. A RAG1 mutation found in Omenn Syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction. J Immunol. 2008 Sep 15;181(6):4124-30. Cited in Pubmed; PMID 18768869.

Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB. Rag mutations reveal robust alternative end joining. Nature. 2007 Sep 27;449(7161):483–6. Cited in Pubmed; PMID 17898768. doi: 10.1038/nature06168.

Wong SY, Roth DB. Murine models of Omenn syndrome (Review). J Clin Invest. 2007 May;117(5):1213-6. Cited in Pubmed; PMID 17476351. PMCID: PMC1857244.