Pamela Sung, M.D., Ph.D.
Internal Medicine-ABIM Research Path, Hospital of the University of Pennsylvania, Philadelphia, PA
NIH CMB Training Grant
William Randolph Hearst Foundation Fellow
BA in Biology and Chemistry, Cornell University
Faculty Mentor: Mark Philips, M.D.
Pam became interested in the biology of cancer through her undergraduate research on GTPases and decided to continue in this field for her thesis work. She is currently characterizing the mechanism of phospho-K-Ras induced cell death as a potential therapeutic approach for K-Ras dependent cancers. On the more basic science side, Pam is also studying the effect of sub-cellular localization of Drosophila Ras on larval eye development in collaboration with Dr. Erika Bach.
Phospho-K-Ras interacts with Bcl-XL and IP3R at the endoplasmic reticulum to regulate calcium homeostasis and autophagy
Cell signaling; Small GTPases; Cancer