Profiles
Navid Sadri, Ph.D.
Fellow in Clerkship, Microbiology
Haverford College
Email:
Faculty Mentor: Robert Schneider, Ph.D.
I have recently defended my thesis "The Knockout Mouse Model Reveals the Diverse Physiological Functions of AUF1" and I am about to start my third year of medical school. In our lab, we employ the knockout mouse model to study the role of AUF1 in mRNA decay, telomere maintenance, as well as other cellular functions.
Thesis
The Knockout Mouse Model Reveals the Diverse Physiological Functions of AUF1
Selected Publications
Sadri N, Schneider RJ. Auf1/Hnrpd-deficient Mice Develop Pruritic Inflammatory Skin Disease. J Invest Dermatol. 2009 Mar;129(3):657-70. Epub 2008 Oct 2. Cited in Pubmed; PMID 18830269. doi: 10.1038/jid.2008.298.
Pautz A, Linker K, Altenhöfer S, Heil S, Schmidt N, Art J, Knauer S, Stauber R, Sadri N, Pont A, Schneider RJ, Kleinert H. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem. 2009 Jan 30;284(5):2755-66. Cited in Pubmed; PMID 19074427. doi: 10.1074/jbc.M809314200.
Lee C, Gyorgy A, Maric D, Sadri N, Schneider RJ, Barker JL, Lawson M, Agoston DV. Members of the NuRD Chromatin Remodeling Complex Interact with AUF1 in Developing Cortical Neurons. Cereb Cortex. 2008;Epub 2008 Apr 15. Cited in Pubmed; PMID 18413351. doi: 10.1093/cercor/bhn051.
Lu JY, Sadri N, Schneider RJ. Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev. 2006 Nov 15;20(22):3174-84. Epub 2006 Nov 3. Cited in Pubmed; PMID 17085481. doi: 10.1101/gad.1467606. PMCID: PMC1635151.
Lu JY, Bergman N, Sadri N, Schneider RJ. Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA. 2006 May;12(5):883-93. Epub 2006 Mar 23. Cited in Pubmed; PMID 16556936. doi: 10.1261/rna.2308106. PMCID: PMC1440908.
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 Mar;11(3):619-33. Cited in Pubmed; PMID 12667446. doi: 10.1016/S1097-2765(03)00105-9.
