Matthew B. Friese, M.D., Ph.D.
Current Position:
Resident in Anesthesiology, Brigham & Women’s Hospital, Mass.
Graduate: 2009, Neuroscience and Physiology
(Biophysics, Johns Hopkins University)
Faculty Mentor: Steven Burden, Ph.D.
As a graduate student in the Department of Physiology and Neuroscience, I investigated how tyrosine phosphorylation of the acetylcholine receptor was involved in forming neuromuscular synapses. I hope to continue this line of research and apply it to clinical patient care as a resident and beyond in the field of Anesthesiology.
Fellowships and Awards: NRSA Ruth L. Kirschstein Individual Predoctoral MD/PhD Fellowship; NRSA Grant NIH National Institute of Neurological Disorders and Stroke.
Thesis
The role of acetylcholine receptor tyrosine phosphorylation in neuromuscular synapse formation
Research Interests
Neuromuscular synapse formation; Acetylcholine receptor; Synaptogenesis
Selected Publications
Borges LS, Yechikhov S, Lee YI, Rudell J, Friese MB, Burden SJ, Ferns MJ. Phosphorylation of a motif in the acetylcholine receptor beta subunit regulates rapsyn association and postsynaptic localization. J Neurosci. 2008 Nov 5;28(45):11468-76. Cited in Pubmed; PMID 18987183.
Friese MB, Blagden CS, Burden SJ. Synaptic differentiation is defective in mice lacking acetylcholine receptor beta-subunit tyrosine phosphorylation. Development. 2007 Dec;134(23):4167-76. Epub 2007 Oct 24. Cited in Pubmed; PMID 17959719. doi:
10.1242/dev.010702.
Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Mol Cell Biol. 2007 Jul;27(13):4759-73. Epub 2007 Apr 23. Cited in Pubmed; PMID 17452444. PMCID: PMC1951494.
Savant-Bhonsale S, Friese M, McCoon P, Montell DJ. A Drosophila derailed homolog, doughnut, expressed in invaginating cells during embryogenesis. Gene. 1999 Apr 29;231(1-2):155-61. Cited in Pubmed; PMID 10231580.
Yahr TL, Mende-Mueller LM, Friese MB, Frank DW. Identification of type III secreted products of the Pseudomonas aeruginosa exoenzyme S regulon. J Bacteriol. 1997 Nov;179(22):7165-8. Cited in Pubmed; PMID 9371466.
Additional Information
Burden Lab
