Profiles
Lauren Young
Graduate Student, Molecular Oncology and Immunology
Harvard University
Email:
Faculty Mentor: Michele Pagano, M.D.
Thesis
Analyzing the screening of proteins that interact with those F-box proteins putatively involved in circadian clock regulation by use of mass spectrometry
Selected Publications
Osterfield M, Egelund R, Young LM, Flanagan JG. Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development. 2008 Mar;135(6):1189-99. Epub 2008 Feb 13. Cited in Pubmed; PMID 18272596. doi: 10.1242/dev.007401.
Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S. The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death. Blood. 2008 Feb 15;111(4):1951-61. Cited in Pubmed; PMID 18024794. doi: 10.1182/blood-2007-05-089219. PMCID: PMC2234044.
Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper AT, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, Dunn A, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Rafii S. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat Med. 2006 May;12(5):557-67. Cited in Pubmed; PMID 16648859. doi: 10.1038/nm1400.
Vincent L, Kermani P, Young LM, Cheng J, Zhang F, Shido K, Lam G, Bompais-Vincent H, Zhu Z, Hicklin DJ, Bohlen P, Chaplin DJ, May C, Rafii S. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest. 2005 Nov;115(11):2992-3006. Cited in Pubmed; PMID 16224539. doi: 10.1172/JCI24586. PMCID: PMC1253622.
Zhang F, Cheng J, Lam G, Jin DK, Vincent L, Hackett NR, Wang S, Young LM, Hempstead B, Crystal RG, Rafii S. Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circ Res. 2005 May 13;96(9):950-7. Cited in Pubmed; PMID 15831817. doi: 10.1161/01.RES.0000165867.95291.7b.
