I am originally from the former USSR and I had always wanted to have a career in medicine. Through college coursework and opportunities in research I realized how exciting and cutting-edge basic science could be and embarked on an undergraduate project studying a protein related to Alzheimer's disease. My research interests have broadened throughout the med-school coursework and currently I am studying how chaperones interact and regulate each-others' functions in the Ron lab. Outside the lab I love to take advantage of being in New York City whether that's biking in Central Park or seeing a show on Broadway (with a student discount, of course!).
Thesis
Regulation of ER Chaperones: Regulated BiP-mediated dissociation of P58 from substrate and modulating BiP’s substrate association by ADP-ribosylation
Research Interests
Diabetes; Proteotoxic stress; Tumorigenesis; Non-oncogene addiction of cancer
Selected Publications
Jin Y, Awad W, Petrova K, Hendershot LM. Regulated release of ERdj3 from unfolded proteins by BiP. EMBO J. 2008 Nov 5;27(21):2873-82. Epub 2008 Oct 16. Cited in Pubmed; PMID 18923428. PMCID: PMC2580786.
Petrova K, Oyadomari S, Hendershot LM, Ron D. Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3. EMBO J. 2008 Nov;27(21):2862-72. Epub 2008 Oct 16. Cited in Pubmed; PMID 18923430. PMCID: PMC2580781.
Haynes CM,
Petrova K, Benedetti C, Yang Y, Ron D. ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans. Dev Cell. 2007 Oct;13(4):467-80. Cited in Pubmed; PMID 17925224. doi:
10.1016/j.devcel.2007.07.016.
Skoberne M, Somersan S, Almodovar W, Truong T,
Petrova K, Henson PM, Bhardwaj N. The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function. Blood. 2006 Aug 1;108(3):947-55. Epub 2006 Apr 13. Cited in Pubmed; PMID 16614246. doi:
10.1182/blood-2005-12-4812. PMCID: PMC1895855.
Jung KM, Tan S, Landman N,
Petrova K, Murray S, Lewis R, Kim PK, Kim DS, Ryu SH, Chao MV, Kim TW. Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. J Biol Chem. 2003 Oct 24;278(43):42161-9. Epub 2003 Aug 11. Cited in Pubmed; PMID 12913006. doi:
10.1074/jbc.M306028200.
Additional Information
Ron Lab
