Profiles
Jon Mallen St. Clair, Ph.D.
Fellow in Clerkship, Cellular and Molecular Biology
NIH NRSA award
BA, University of California, Berkeley
Email:
Faculty Mentor: Dafna Bar-Sagi, Ph.D.
I just started my fifth year in the program. I’m working on how high fat diets and hyperlipidemia cause pancreatic inflammation and may play a role in pancreatic cancer progression. A newly developing project is examining the role of chromatin remodeling complexes in pancreatic inflammation and cancer. For fun I enjoy cooking, sports, and going out in the city with friends.
Thesis
Investigating the role of chronic inflammation in pancreatic cancer
Research Interests
The role of inflammation in cancer development; Diseases of the pancreas; Epigenetics; Mast cells
Selected Publications
Connolly MK, Bedrosian AS, Mallen-St Clair J, Mitchell AP, Ibrahim J, Stroud A, Pachter HL, Bar-Sagi D, Frey AB, Miller G. In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha. J Clin Invest. 2009 Nov;119(11):3213-25. Epub 2009 Oct 12. Cited in Pubmed; PMID 19855130. doi: 10.1172/JCI37581. PMCID: 2769179.
Ojima I, Chen J, Sun L, Borella CP, Wang T, Miller ML, Lin S, Geng X, Kuznetsova L, Qu C, Gallager D, Zhao X, Zanardi I, Xia S, Horwitz SB, Mallen-St Clair J, Guerriero JL, Bar-Sagi D, Veith JM, Pera P, Bernacki RJ. Design, synthesis, and biological evaluation of new-generation taxoids. J Med Chem. 2008 Jun 12;51(11):3203-21. Epub 2008 May 9. Cited in Pubmed; PMID 18465846. doi: 10.1021/jm800086e.
Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun 3;13(6):719-24. Epub 2007 Jun 3. Cited in Pubmed; PMID 17546038. doi: 10.1038/nm1601.
Mallen-St Clair J, Shi GP, Chapman HA, Wolters PJ. Cathepsins L and S are not Required for Activation of Dipeptidyl Peptidase I (cathepsin C) in Mice. Biol Chem. 2006 Aug;387(8):1143-6. Cited in Pubmed; PMID 16895486. doi: 10.1515/BC.2006.141.
Wolters PJ, Mallen-St Clair J, Lewis CC, Villalta SA, Baluk P, Erle DJ, Caughey GH. Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice. Clin Exp Allergy. 2005 Jan;35(1):82-8. Cited in Pubmed; PMID 15649271. doi: 10.1111/j.1365-2222.2005.02136.x.
Mallen-St Clair J, Pham CT, Villalta SA, Caughey GH, Wolters PJ. Mast cell dipeptidyl peptidase I mediates survival from sepsis. J Clin Invest. 2004 Feb;113(4):628-34. Cited in Pubmed; PMID 14966572. doi: 10.1172/JCI19062.
Bhagwandin VJ, Hau LW, Mallen-St Clair J, Wolters PJ, Caughey G. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31;278(5):3363-71. Epub 2002 Nov 18. Cited in Pubmed; PMID 12441343. doi: 10.1074/jbc.M209353200.
