Profiles
Jon Maffie
Graduate Student, Neuroscience and Physiology
BA Biology, Chemistry, Psychology, Cornell University
Email:
Faculty Mentor: Bernardo Rudy, M.D., Ph.D.
Jon’s current research interest in the regulation of ion channels that produce the information carrying electrical signals of the brain grows out of a long standing interest in the nature and physical instantiation of human mental phenomena.
Thesis
Molecular and electrophysiological characterization of the role of DPP6 in somatodendritic A-type currents
Research Interests
How the brain works; Autism spectrum disorders; Molecular mechanism of neuronal excitability; Functional connectivity of neurons
Selected Publications
Constantinople CM, Disney AA, Maffie J, Rudy B, Hawken MJ. Quantitative analysis of neurons with Kv3 potassium channel subunits, Kv3.1b and Kv3.2, in macaque primary visual cortex. J Comp Neurol. 2009 Oct 1;516(4):291-311. Cited in Pubmed; PMID 19634181. doi: 10.1002/cne.22111.
Maffie J, Blenkinsop T, Rudy B. A novel DPP6 isoform (DPP6-E) can account for differences between neuronal and reconstituted A-type K(+) channels. Neurosci Lett. 2009 Jan 16;449(3):189-94. Epub 2008 Nov 5. Cited in Pubmed; PMID 19007856. doi: 10.1016/j.neulet.2008.10.098.
Rudy B, Maffie J, Amarillo Y, Clark B, Goldberg EM, Jeong HY, Kruglikov I, Kwon E, Nadal M, Zagha E. Structure and Function of Voltage-Gated K+ Channels: Kv1 to Kv9 Subfamilies. In: Squire LR, editor. Encyclopedia of Neuroscience. Volume 10. Oxford: Academic Press; 2009. pp. 397-425.
Maffie J, Rudy B. Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons. J Physiol. 2008 Dec 1;586(Pt 23):5609-23. Epub 2008 Oct 9. Cited in Pubmed; PMID 18845608.
Clark BD, Kwon E, Maffie J, Jeong HY, Nadal M, Strop P, Rudy B. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci. 2008 Oct;1:8. Epub 2008 Oct 23. Cited in Pubmed; PMID 18978958. doi: 10.3389/neuro.02.008.2008. PMCID: PMC2576564.
Amarillo Y, De Santiago-Castillo JA, Dougherty K, Maffie J, Kwon E, Covarrubias M, Rudy B. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons. J Physiol. 2008 Apr 15;586(8):2093-106. Epub 2008 Feb 14. Cited in Pubmed; PMID 18276729. PMCID: PMC2465190 [Available on 04/15/09].
