Edward Zagha, Ph.D.
Fellow in Clerkship, Neuroscience and Physiology
NIH NSRA Grant
BS Biological Sciences, Stanford University
Email:
Faculty Mentor: Bernardo Rudy, M.D., Ph.D.
Upon entering medical school I decided to study the electrical properties of the nervous system, with the goal of gaining insight into the biological basis of cognition and movement. Having completed my PhD, I recently returned to the wards and am attempting to re-engage clinic medicine. I am still undecided whether I will continue to pursue research or medicine following medical school.
Thesis
Molecular mechanisms of cerebellar Purkinje cell excitability
Research Interests
Organization and activities of neurons that enables the output of the nervous system, particularly movement and cognition
Selected Publications
Rudy B, Maffie J, Amarillo Y, Clark B, Goldberg EM, Jeong HY, Kruglikov I, Kwon E, Nadal M, Zagha E. Structure and Function of Voltage-Gated K+ Channels: Kv1 to Kv9 Subfamilies. In: Squire LR, editor. Encyclopedia of Neuroscience. Volume 10. Oxford: Academic Press; 2009. pp. 397-425.
Goldberg EM,
Clark BD,
Zagha E, Nahmani M, Erisir A, Rudy B. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron. 2008 May 8;58(3):387-400. Cited in Pubmed; PMID 18466749. doi:
10.1016/j.neuron.2008.03.003. PMCID: PMC2730466.
Zagha E, Lang EJ, Rudy B. Kv3.3 channels at the Purkinje cell soma are necessary for generation of the classical complex spike waveform. J Neurosci. 2008 Feb 6;28(6):1291-300. Cited in Pubmed; PMID 18256249. doi:
10.1523/JNEUROSCI.4358-07.2008.
Makani S,
Zagha E. Out of the cleft: the source and target of extra-synaptic glutamate in the CA1 region of the hippocampus. J Physiol. 2007 Jul 15;582:479-80. Cited in Pubmed; PMID 17556385. doi:
10.1113/jphysiol.2007.137059. PMCID: PMC2075323.
Chang SY,
Zagha E, Kwon ES, Ozaita A, Bobik M, Martone ME, Ellisman MH, Heintz N, Rudy B. Distribution of Kv3.3 potassium channel subunits in distinct neuronal populations of mouse brain. J Comp Neurol. 2007 Jun 20;502(6):953-72. Cited in Pubmed; PMID 17444489. doi:
10.1002/cne.21353.
Zagha E, Ozaita A, Chang SY, Nadal MS, Lin U, Saganich MJ, McCormack T, Akinsanya KO, Qi SY, Rudy B. DPP10 modulates Kv4-mediated A-type potassium channels. J Biol Chem. 2005 May 13;280(19):18853-61. Epub 2005 Jan 25. Cited in Pubmed; PMID 15671030. doi:
10.1074/jbc.M410613200.
