Profiles
Edward Geisinger, Ph.D.
Fellow in Clerkship, Microbiology
BS Biology and French, Duke University
Email:
Faculty Mentor: Richard Novick, M.D.
While in the Novick lab, Eddie studied the virulence mechanisms of Staphylococcus aureus, including its use of chemical signaling to coordinate toxin production during infection. Four years and several thousand Petri dishes later, he has returned to the wards.
Thesis
Studies on the Molecular Mechanisms of Staphylococcal Quorum Sensing
Research Interests
Bacteriology; Signal transduction; Receptor biology
Selected Publications
Cisar EG*, Geisinger E*, Muir TW, Novick RP. Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. Mol Microbiol. 2009 Aug;Epub 2009 Aug 24. Cited in Pubmed; PMID 19708918. doi: 10.1111/j.1365-2958.2009.06849.x.
Geisinger E, Muir TW, Novick RP. agr receptor mutants reveal distinct modes of inhibition by staphylococcal autoinducing peptides. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1216-21. Cited in Pubmed; PMID 19147840. doi: 10.1073/pnas.0807760106. PMCID: PMC2633565.
Novick RP, Geisinger E. Quorum sensing in staphylococci. Annu Rev Genet. 2008 Dec;42:541-64. Cited in Pubmed; PMID 18713030. doi: 10.1146/annurev.genet.42.110807.091640.
Geisinger E, George EA, Muir TW, Novick RP. Identification of ligand specificity determinants in AgrC, the Staphylococcus aureus quorum-sensing receptor. J Biol Chem. 2008 Apr;283(14):8930-8. Cited in Pubmed; PMID 18222919. PMCID: PMC2276371.
Geisinger E, Novick RP. Signal integration and virulence gene regulation in S. aureus. In: Winans S, Bassler B. Chemical Communication among Bacteria. Washington, D.C.: Am. Soc. Micro. Press; 2008. pp. 161-184.
Geisinger E, Adhikari RP, Jin R, Ross HF, Novick RP. Inhibition of rot translation by RNAIII, a key feature of agr function. Mol Microbiol. 2006 Aug;61(4):1038-48. Cited in Pubmed; PMID 16879652. doi: 10.1111/j.1365-2958.2006.05292.x.
Yao J, Zhong J, Fang Y, Geisinger E, Novick RP, Lambowitz AM. Use of targetrons to disrupt essential and nonessential genes in Staphylococcus aureus reveals temperature sensitivity of Ll.LtrB group II intron splicing. RNA. 2006 Jul;12(7):1271-81. Epub 2006 Jun 1. Cited in Pubmed; PMID 16741231. doi: 10.1261/rna.68706. PMCID: PMC1484445.
