Christopher Cardinale, Ph.D.
Fellow in Clerkship, Cellular and Molecular Biology
BA Biochemical Sciences, Harvard University
Email:
Faculty Mentor: Evgeny Nudler, Ph.D.
Chris is now on his third-year rotations and he is enjoying the constant churn of new colleagues, patients, and knowledge. He hasn't quite figured out what career he will pursue but he hopes to find a niche in infectious disease and host-pathogen interaction. His favorite local hangout is the Waterfront, where you can enjoy any of twenty different beers on tap.
Thesis
Genome-wide Analysis of Transcriptional Termination in Escherichia coli
Research Interests
Many aspects of transcription in E. coli, including termination, Rho factor, transcription kinetics, and the mechanisms of transcript elongation and fidelity by the RNA polymerase
Selected Publications
Cardinale CJ*, Washburn RS*, Tadigotla VR, Brown LM, Gottesman ME, Nudler E.
Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli. Science. 2008 May 16;320(5878):935-8. Cited in Pubmed; PMID 18487194. doi:
10.1126/science.1152763.
Epshtein V,
Cardinale CJ, Ruckenstein AE, Borukhov S, Nudler E. An allosteric path to transcription termination. Mol Cell. 2007 Dec 28;28(6):991-1001. Cited in Pubmed; PMID 18158897. doi:
10.1016/j.molcel.2007.10.011.
Fournier E,
Isakoff SJ, Ko K,
Cardinale CJ, Inghirami GG, Li Z, Curotto de Lafaille MA, Skolnik EY. The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses. Curr Biol. 2003 Oct 28;13(21):1858-66. Cited in Pubmed; PMID 14588241. doi:
10.1016/j.cub.2003.09.034.
Cardinale CJ, Ko K, Dworkin LD, Shaw AS, Skolnik EY. A potential role for integrin beta 6-mediated activation of TGF-beta in the progression of chronic renal disease (Abstract). J Am Soc Nephrol. 2003;14:373A Suppl. S.
