Profiles
Brian D. Clark
Graduate Student, Neuroscience and Physiology
NRSA Grant from the National Institute of Neurological Disorders and Stroke (NINDS)
BS Neuroscience, University of Minnesota, Twin Cities
Email:
Faculty Mentor: Bernardo Rudy, M.D., Ph.D.
My long-term goal is to understand better global brain function in health and disease. I’m currently studying one of the nervous system’s remarkable specializations—its excitable membranes and the cells to which they belong.
Thesis
Functional roles of Kv1 channels in neocortical fast-spiking interneurons
Research Interests
Intrinsic excitability and integrative properties of cortical neurons; Ion channels; Inhibition; Synaptic transmission; Cellular organization of brain tissue (anatomy)
Selected Publications
Clark BD, Goldberg EM, Rudy B. Electrogenic tuning of the axon initial segment (review). Neuroscientist. Forthcoming 2009.
Rudy B, Maffie J, Amarillo Y, Clark B, Goldberg EM, Jeong HY, Kruglikov I, Kwon E, Nadal M, Zagha E. Structure and Function of Voltage-Gated K+ Channels: Kv1 to Kv9 Subfamilies. In: Squire LR, editor. Encyclopedia of Neuroscience. Volume 10. Oxford: Academic Press; 2009. pp. 397-425.
Clark BD, Kwon E, Maffie J, Jeong HY, Nadal M, Strop P, Rudy B. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein. Front Mol Neurosci. 2008 Oct;1:8. Epub 2008 Oct 23. Cited in Pubmed; PMID 18978958. doi: 10.3389/neuro.02.008.2008. PMCID: PMC2576564.
Goldberg EM, Clark BD, Zagha E, Nahmani M, Erisir A, Rudy B. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons. Neuron. 2008 May 8;58(3):387-400. Cited in Pubmed; PMID 18466749. doi: 10.1016/j.neuron.2008.03.003. PMCID: PMC2730466.
