Alexander Spektor, M.D., Ph.D.
Current Position:
Preliminary Medicine at Beth Israel Deaconess Medical Center, Boston, followed by the Harvard Radiation Oncology Program at Brigham and Women's Hospital.
Graduate: 2009, Molecular Oncology and Immunology
Department of Defense Prostate Cancer Predoctoral Fellowship
AΩA Medical Honor Society
(BA Biology and Chemistry, cum laude, Cornell University)
Faculty Mentor: Brian Dynlacht, Ph.D.
Born in Riga, Latvia, Alex moved to the United States with his family in 1992. His research interests include understanding centrosome function throughout cell cycle and studying the role of centrosomes in prevention of tumor formation and progression. Alex was an MD/PhD Representative to the NYU School of Medicine Student Council and was actively involved in the program throughout his time here.
Thesis
Identification and Characterization of CP110-interacting Proteins in Centrosome Function
Research Interests
Key events of the centrosome cycle - centrosome duplication, separation and ciliogenesis; Role of centrosomes in the maintenance of genomic stability and prevention of tumorigenesis
Selected Publications
Kohlmaier G, Loncarek J, Meng X, McEwen BF, Mogensen MM,
Spektor A, Dynlacht BD, Khodjakov A, Gönczy P. Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. Curr Biol. 2009 Jun 23;19(12):1012-8. Epub 2009 May 28. Cited in Pubmed; PMID 19481460. doi:
10.1016/j.cub.2009.05.018.
Tsang WY*,
Spektor A*, Vijayakumar S, Bista BR, Sanchez I, Duensing S, Dynlacht BD. Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication. Dev Cell. 2009 May 19;16(5):649–60. Cited in Pubmed; PMID 19460342. doi:
10.1016/j.devcel.2009.03.004.
Spektor A, Tsang WY, Khoo D, Dynlacht BD. Cep97 and CP110 suppress a cilia assembly program. Cell. 2007 Aug 24;130(4):678-90. Cited in Pubmed; PMID 17719545. doi:
10.1016/j.cell.2007.06.027.
Tsang WY,
Spektor A, Luciano DJ, Indjeian VB, Chen Z, Salisbury JL, Sánchez I, Dynlacht BD. CP110 Cooperates with Two Calcium-binding Proteins to Regulate Cytokinesis and Genome Stability. Mol Biol Cell. 2006 Aug;17(8):3423-34. Epub 2006 Jun 7. Cited in Pubmed; PMID 16760425. doi:
10.1091/mbc.E06-04-0371. PMCID: PMC1525247.
Balciunaite E,
Spektor A, Lents NH, Cam H, Te Riele H, Scime A, Rudnicki MA, Young R, Dynlacht BD. Pocket protein complexes are recruited to distinct targets in quiescent and proliferating cells. Mol Cell Biol. 2005 Sep;25(18):8166-78. doi:
10.1128/MCB.25.18.8166-8178.2005. PMCID: PMC1234327.
Cam H, Balciunaite E, Blais A,
Spektor A, Scarpulla RC, Young R, Kluger Y, Dynlacht BD. A common set of gene regulatory networks links metabolism and growth inhibition. Mol Cell. 2004 Nov 5;16(3):399-411. Cited in Pubmed; PMID 15525513. doi:
10.1016/j.molcel.2004.09.037.
Medical Specialization
Radiation Oncology
Additional Information
Dynlacht Lab
