March 12, 20132013 NYU MSTP Research Retreat
This past weekend, March 8 through March 10, students, staff, and faculty members took part in the 2013 MSTP Research Retreat at the Stratton Mountain Ski Resort in Vermont. The weekend featured student and faculty talks, poster sessions, a panel discussion on being a physician-scientist, and a keynote lecture as well as plenty of free time to socialize, hit the slopes, shop, and enjoy the snowy New England winter scenery.
Students, faculty, and staff gather outside the Stratton Mountain Inn before hitting the slopes.
The MSTP invited special guest Jonathan Chernoff, MD, PhD, to give the keynote lecture entitled, "p21-activated kinases as targets for cancer therapy." Dr. Chernoff is Senior Vice President, Scientific Director, and Stanley P. Reimann Chair in Oncology Research at the Fox Chase Cancer Center in Philadelphia, PA.
Faculty lectures included:
Niels Ringstad, PhD: Deconstructing and reconstructing neurons that sense the respiratory gas carbon dioxide
Kenneth Cadwell, PhD: Gene-microbe interactions in intestinal disease
Work-in-progress talks were given by:
Stephen Armenti: Mechanisms of small GTPase-mediated regulation of polarization and organogenesis
Adam Blaisdell: Innate immune surveillance and inflammation in the control of premalignant tumor growth and progression
Christopher Bowman: Identifying and characterizing functionally distinct Sin3 complexes
Joseph Cichon: Branch-specific dendritic calcium spikes induce synaptic plasticity in vivo
Jesse Handler: Influence of tissue stiffness on cytokine profile of pancreatic cancer cells
Melissa McKenzie-Chang: A novel gradient in the developing forebrain delineates the specification of principal cortical interneuron cell types
Frederick Tsai: The neglected isoform of Ras: cellular expression and localization of K-Ras4A
Jordan Wengrod: Regulation of autophagy: cross talk between two vital nutrient sensing pathways
Danielle Zheng: Food restriction increases preference for a cocaine-paired environment
Poster presentations were given by:
Stephen Armenti: Mechanisms of small GTPase-mediated regulation of polarization and organogenesis
Andrew Beenken, PhD: A molecular basis for FGF gradient formation and its role in branching morphogenesis
Stephen Berger: Role of phosphorylated MLC2 at polarized axonal domains
Adam Blaisdell: Innate immune surveillance and inflammation in the control of premalignant tumor growth and progression
Tyler Bold, PhD: Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo
Christopher Bowman: Identifying and characterizing functionally distinct Sin3 complexes
Emily Chan: Mechanisms of CDC-42 activation during contact-induced cell polarization
Joseph Cichon: Branch-specific dendritic calcium spikes induce synaptic plasticity in vivo
Jesse Handler: Influence of tissue stiffness on cytokine profile of pancreatic cancer cells
Maryem Hussein: The effects of hyperglycemia on macrophage gene expression in the context of atherosclerosis
Justin Jee: Visualizing the spread of ideas via an information-theoretic framework
Stephen Lewellis: Chemokine sequestration generates an attractant gradient across collectively migrating cells
Alexandra Livanos: Effect of antibiotic-induced gut microbiota perturbation on the development of type 1 diabetes (T1D) in non-obese diabetic (NOD) mice
Jon Maffie, PhD: Molecular components of the A-type potassium channels control channel function, distribution and behavior
Joseph Marlin: Dendritic inhibition in laer 5 pyramidal neurons of the medial prefrontal cortex
Melissa McKenzie-Chang: A novel gradient in the developing forebrain delineates the specification of principal cortical interneuron cell types
Xiaosong Meng, PhD: The Necl-4, Par-3 and 4.1G complex promotes Schwann cell myelin sheath formation and integrity
William Munoz-Miranda: Cellular and molecular basis of cholinergic activation of the cortex
Daniel Okobi: Progress towards two-photon microscopy in singing zebra finches
Karen Ong: Computational modeling of the horizontal transmission of Klebsiella in the ICU
Christopher Parkhurst: Absence of microglia results in defective learning and synaptic remodeling in adult mice
Adam Pont, PhD: AUF1 regulates p15lnk4A expression, telomerase levels, and telomere length in a mouse model of accelerated aging
Stephen Rawlings: Clearing and preventing latent HIV-1 infection of CD4+ T-cells
Amy Sun: VH-replacement as a mechanism of diversification of the primary antibody repertoire
Nicole Sunseri, PhD: Efficient transduction of myeloid cells by an HIV-1-derived lentiviral vector that packages the Vpx accessory protein
Frederick Tsai: The neglected isoform of Ras: cellular expression and localization of K-Ras4A
John Wang: Elucidating the role of kal1 in zebrafish lateral line development
Jordan Wengrod: Regulation of autophagy: cross talk between two vital nutrient sensing pathways
Lauren Young: Characterization of the TIMELESS-PARP1 interaction during DNA damage
Danielle Zheng: Food restriction increases preference for a cocaine-paired environment
Angela Zhou: GARP-TGFb complexes negatively regulate Treg cell development and maintenance of peripheral CD4+ T cells in vivo
Breakfast panel discussion, "On Being a Physician Scientist," was led by:
August 20, 2012First Years Inaugurated into Medical School

First years pose with MSTP Director Mark Philips, M.D., at the 2012 White Coat Ceremony
After spending their summer conducting laboratory research with Sackler faculty, the 11 first year MSTP students were welcomed into the NYU School of Medicine with the Class of 2016 at the White Coat Ceremony on August 17. During the ceremony, medical students were cloaked in their first white coats by specially selected faculty in the presence of family, friends, and colleagues as a symbol of the beginning of their careers as medical students. They then took an oath, similar to the Hippocratic oath, stressing the importance of ethics, honesty, compassion and the doctor-patient relationship in medicine.
June 13, 2012Eleven new students have joined the MD/PhD Program
The NYU MSTP welcomes eleven new students to the program after another successful recruiting season. We are delighted to introduce the following newest members into our student community:
Camila Delgado (BS in Biomedical Engineering, Florida International University)
Alice Fok (BS in Biological Chemistry and Chemistry, University of Chicago)
Joshua Horton (BS in Biochemistry, Indiana University)
Kalman Katlowitz (BE in Interdisciplinary Engineering, Cooper Union)
Julia King (BS in Chemistry and Neuroscience, University of Virginia)
Rose Levenson-Palmer (BA in Biology, Columbia University)
Ashira Lubkin (BA in Biology, Columbia University)
Shirin Mortazavi (BS in Biochemistry, University of Texas at Austin)
Charles Ng (BS in Biophysics, University of California, Los Angeles)
Evan Rosenberg (BS in Biology and Neuroscience, Brandeis University)
Roland Zemla (BS in Biochemistry, Columbia University)
These first-year students will begin their medical training on August 20 after completion of the MSTP Summer Seminar Series and their first summer rotations in the labs of NYU faculty researchers including Erika Bach, Georgy Buzsaki, Brian Dynlacht, Joel Ernst, Stevan Hubbard, Dan Littman, Ian Mohr, Michele Pagano, Charles Peskin, Richard Tsien, and Angus Wilson.
Over 100 faculty members and 22 members of the recruitment committee reviewed applications of more than 400 prospective candidates last fall. Invitations were extended after five intensive interviewing-day sessions to applicants from a cross-section of outstanding undergraduate institutions including Berkeley, Brandeis, Brown, Chicago, Columbia, Harvard, Johns Hopkins, Penn, Princeton, Stanford, UCLA, UVA, and Yale.
The admissions committee and MSTP Director Dr. Mark Philips were very impressed with the exceptional qualities of all of this year's applicants.
April 3, 2012 New MD/PhD Administrative Offices
Please join the MSTP family in welcoming Heather Petrucci to the the MD PhD Program. Heather is the newly appointed Program Coordinator replacing Polina Miklush.
Heather can be reached at 212-263-2149 or via email at
March 29, 2012 Alpha Omega Alpha Medical Honor Society: Class of 2012 Member
One of our graduating MSTP Fellows was inducted as new member of the Alpha Omega Alpha Medical Honor Society at a ceremony held March 29, 2012. Ian Ahearn was among the 27 NYU School of Medicine students who were selected to become part of the AΩA Class of 2012. The election by a faculty committee to the AΩA Honor Society represents an acknowledgement of the highest standards of excellence achieved by graduating medical students. In 2011, MSTP graduates Amelie Collins and Santosha Vardhana were two of those honored by the AΩA Society.
Founded in 1902, Alpha Omega Alpha is the national medical honor society. Its mission, in part, is to recognize high educational achievement, encourage the development of leaders in academia and the community, and to promote service to others in the profession of medicine. Students are chosen for election by their school chapters. Members are selected not only for their high academic standing in the top quartile of their class, but also for criteria such as leadership among their peers, professionalism and a firm sense of ethics, promise of future success in medicine, and a commitment to service in the school and community.
March 16, 2012 Seven students will graduate this May
We will say goodbye to seven graduates from the MSTP in May, 2012. Once again, this year's newest alumni of our MD/PhD Training Program have distinguished themselves in their residency matches. Plans for our graduates include:
Ian Ahearn: Preliminary Medicine -- Greenwich Hospital, CT; PGY2 Dermatology -- NYU School of Medicine, NY
Viet Bui: Internal Medicine Residency -- Harbor-UCLA Medical Center, Los Angeles, CA
Scott Drutman: Internal Medicine/Research -- NY Presbyterian Hospital-Weill Cornell Medical Center, NY
Eugene Friedman: Internal Medicine Residency -- NYU School of Medicine, NY
Celine Mestel: Preliminary Medicine -- Lenox Hill Hospital, New York; PGY2 Dermatology -- SUNY Hospital Center, Brooklyn, NY
Pamela Sung: Internal Medicine-ABIM Research Path -- Hospital of the University of Pennsylvania, Philadelphia, PA
Kay Yeung: Internal Medicine/Investigator Path -- UC San Diego Medical Center, CA
We would like to congratulate them all for their superlative achievements and extend our best and heart-felt wishes for their future careers!
July 1, 2011 Eleven new students have joined the NYU MD/PhD Program
Eleven new students have joined the NYU Medical Scientist Training Program for this academic year, capping the efforts of another successful recruiting year for the MD/PhD Program. We are pleased to welcome the following newest members to our student community:
Omotayo Arowojolu (Johns Hopkins University)
Hannah Bernstein (Stanford University)
David Cantor (Pennsylvania State University)
John Dankert (Rochester Institute of Technology)
Jessica Douthit (Temple University)
Victoria Fang (Amherst College)
Marcus Hines (University of Georgia)
Luis Martinez (Harvard University)
Laura McGarry (Columbia University)
Aram Modrek (University of California, Irvine)
Karishma Rahman (Massachusetts Institute of Technology)
After the conclusion of the MSTP Summer Seminar, the first-year students will start their medical training on August 22. They are also scheduled to rotate through the labs of a number of researchers, including the labs of Adam Carter, Bruce Cronstein, Moses Chao, Robert Froemke, Michelle Krogsgaard, Michele Pagano, Mark Philips, Niels Ringstad, and Naoko Tanese.
More than 100 faculty members and twenty-two members of the recruitment committee reviewed the applications of almost 400 prospective candidates last fall. After seven intensive interviewing-day sessions, the MSTP extended invitations to applicants from a cross-section of outstanding undergraduate institutions, including Berkeley, Brown, Columbia, Dartmouth, Georgetown, Harvard, Johns Hopkins, MIT, Northwestern, Penn, Princeton, Stanford, Swarthmore, UCLA, and Yale.
The Admissions Committee and the Director of the MSTP, Dr. Mark Philips, were very impressed with the sterling qualities of all of this year's applicants.
April 25, 2011 Changes in Leadership at the NYU MSTP
David B. Roth, MD, PhD, the Irene Diamond Professor of Immunology, has decided to step down as Director of the MD/PhD Program and will relinquish his duties as of July 2011. Since Dr. Roth took over the stewardship of the Program in early 2008, he has steered the NYU MSTP through a period of structural and conceptual changes, as well as an administrative transition, in order to guarantee the continued funding of its training grant by the National Institutes of Health.
Taking over the helm as Program Director is Mark R. Philips, MD, Professor of Medicine, Cell Biology, and Pharmacology, and Associate Director for Basic Research at the NYU Cancer Institute. In his capacity as Associate or Co-Director of the MSTP, Dr. Philips has served the NYU School of Medicine MD/PhD Program since 1998, and the change in leadership should underscore this continuity. Dr. Philips commended his predecessor and noted, "I am profoundly grateful for David's work as a Director. The NYU MSTP has never been in better shape, thanks to his tireless efforts on behalf of the program."
After graduating from Columbia College of Physicians and Surgeons, Dr. Philips came to Bellevue for his residency training in 1982 and completed a rheumatology fellowship at NYU in 1988. He subsequently completed a postdoctoral fellowship in the Department of Cell Biology. In addition to running a basic research laboratory that studies the membrane targeting and processing of GTPases, he maintains clinical involvement as an Attending in the Department of Medicine. He has trained numerous MSTP Fellows in his laboratory.
March 4, 2011 2010-2011 Dr. Stanley Minkowitz Memorial Scholarship Award
This year's recipient of the Dr. Stanley Minkowitz Memorial Scholarship Award for the NYU MSTP is Joe Marlin, a first-year graduate student in the Sackler Institute of Biomedical Sciences.
Joe Marlin holds a Bachelor of Arts in Neuroscience and Bachelor of Science in Chemistry from the University of California, Berkeley. He joined the NYU Medical Scientist Training Program in 2008. Under the mentorship of Moses Chao, Joe is currently investigating the development and plasticity of inhibitory synapses in the mammalian central nervous system, focusing on the role of neurotrophins such as brain-derived neurotrophic factor (BDNF.) Inhibitory neurotransmission plays an essential role in modulating circuit activity for the generation of meaningful rhythms and behaviors, while preventing epileptiform activity. BDNF and other neurotrophins are implicated in various neurologic and psychiatric diseases involving excitation-inhibition imbalance, such as epilepsy, Parkinson's disease, and depression.
In many ways, Joe Marlin's trajectory into the NYU MD/PhD Program echoes the experience of other budding physician-scientists. He has always loved the humanistic aspect of medicine and medicine was his field of choice growing up, but he also found deep intellectual satisfaction performing bench research in the laboratory of Prof. Carlos Bustamante at Berkeley. Midway through college Joe discovered the option of MD/PhD programs. As he states, "my hope is to pursue a career in which my basic neuroscience research will translate directly to my clinical practice. I also look forward to playing the role of an educator for future generations of medical and graduate students."
Joe was exposed to the training environment at NYU in the summer of 2007 as a "SURPie," a student in the competitive Summer Undergraduate Research Program. The SURP is offered by the Sackler Institute under the auspices of Dr. Joel Oppenheim, who is the recipient of the 2010 AAAS Mentor Award for Lifetime Achievement. As Joe recalls, "that summer is one of the most memorable of my life, full of late nights in the Ziff lab, wandering around the city with my SURPies, and getting to know the Sackler administration, notably Dr. Joel Oppenheim."
Dr. David Roth, the director of the NYU MSTP, notes, "SURP is a great way for undergraduate students to find out if they have what it takes to become physician-scientists since the program requires you to do graduate-level work in a research lab. I am very grateful to Dr. Minkowitz for the scholarships in his name to support MSTP students because they allow promising trainees such as Joe to approach scientific problems with the broad perspective of a physician-scientist."
The Minkowitz Memorial Scholarships are a tribute to the memory of Dr. Stanley Minkowitz, Dr. Gerald Minkowitz's father. Dr. Stanley Minkowitz was a clinically oriented pathologist whose endeavors focused on training young pathologists in both practical, clinical, and research pathology. He was Director of Pathology at Maimonides Medical Center for over 20 years and a Professor of Pathology at SUNY Downstate Medical Center.
The scholarships are made possible by the generous support of philanthropists Dr. and Mrs. Gerald Minkowitz, who established the fellowship in 2009 and who have donated more than $160,000 in support of biomedical education at NYU to date. Dr. Minkowitz is currently Laboratory Director of Minkowitz Pathology and Adjunct Assistant Professor of Pathology at NYU School of Medicine with a strong interest in medical and science education. Dr. Minkowitz received a BS in Bioengineering from Columbia University and was a Guest Investigator at Rockefeller University under the supervision of Günter Blobel. Following an AP/CP Residency at the New York Hospital-Cornell Medical Center and a Cytopathology Fellowship at the Lankenau Hospital, he was Assistant Professsor of Pathology at NYU School of Medicine and Assistant Attending Pathologist at Bellevue Hospital. He established the Brooklyn-based Minkowitz Pathology Labs, specializing in Ultrasound-Guided FNA, Surgical Pathology, Cytopathology, and Applied Clinical Research, in 1994.
In addition to the Minkowitz Fellowships, about 15 percent of the MSTP trainees have already secured independent funding through Ruth L. Kirschstein National Research Service Award Individual Fellowships. Among the current students who have received individual support through NIH funding agencies are Yelina Alvarez (NIAID), Stephen Armenti (NIDDK), Tyler Bold (NHLBI), Chris Bowman (NIA), Jason Chalifoux (NIMH), Brian Clark (NINDS), Scott Drutman (NIA), Dorota Korta (NIDDK), Jon Maffie (NINDS), Jon Mallen St. Clair (NIAAA), Melissa McKenzie (NIMH), Xiaosong Meng (NINDS), and Maureen Nemetski (NHLBI).
The William Randolph Hearst Foundation has also generously supported the NYU MSTP training. The 2010-11 William Randolph Hearst Foundation Fellows are Ijeoma Ejigiri, Pamela Sung, and Roseanne Titcombe. A total of 30 scholarships have been awarded to 16 Hearst Fellows in the MD/PhD Medical Scientist Training Program, with scholarship funds nearing half a million dollars since the inception of the Hearst Fellowship Program in 1999.
Other donor and endowment funds that have supported trainees in the MSTP are the Norman & Rosita Winston Foundation/Paul R. Esserman Memorial Fund, the Saul Krugman Endowment Fund, the Doris Milman-Nathan Kreeger Endowment Fund, and the Arthur C. DeGraff Endowment fund.
January 15, 2011 2011 NYU MSTP Winter Research Retreat
This year's MSTP Student Research Retreat was held from February 11 to February 13 at the Stratton Mountain Inn in Stratton, Vermont. The MSTP Retreat is an important annual forum for the community of MSTP physician-scientists training at NYU. The retreat featured student talks, poster sessions, a panel discussion "On Being a Physician Scientist," and a keynote lecture, along with ample free time to socialize and to enjoy the New England winter scenery, and was attended by 80 percent of the MSTP students. The talks by Tyler Bold and Chris Parkhurst were selected by their peers as the retreat's best research presentations.

The activities included work-in-progress talks by:
Yelina Alvarez: Restoration of TH17 Response during HIV infection by HIV inhibiting drugs and TH17 differentiating cytokines
Andrew Beenken: Plasticity in the interactions of FGF1 N-terminus with FGF receptors underlies FGF1'S promiscuity
Tyler Bold: CD4+ and CD8+ effector T cell tuning in M.tuberculosis infection
Stephen Lewellis: Chemokine receptor cooperation mediates trigeminal ganglion assembly
Xiaosong Meng: Evidence for a Necl-4, Par-3 and 4.1G Complex in Myelinating Schwann Cells
Scott Millman: SCF-ubiquitin ligases: Regulation of the NF-κB signaling pathway
Christopher Parkhurst: Generation and characterization of a CX3CR1-CreER mouse for the study of microglia function in the CNS
Adam Pont: Investigating the role of AUF1 in p16Ink4A Expression and telomere length maintenance
Stephen Rawlings: P-body component Mov10 perturbs HIV-1 infectivity
Joseph Wynne: Rap1 and Riam signaling in T cells
Poster presentations were provided by:
Stephen Armenti: In vivo analysis of epithelial cell polarization
David Beck: Regulation of the histone H4 monomethylase PR Set7 is required for proper cell cycle progression and DNA damage response
Andrew Beenken: A molecular basis for FGF gradient formation and its role in branching morphogenesis
Tyler Bold: Low frequency activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in mice
Emily Chan: Regulation of Radial Polarity and RhoGTPase Signaling in the Early C. elegans Embryo
Dorota Korta: RSKS-1/S6K and germline proliferation in C. elegans
Jon Maffie: Loss of the autism associated gene DPP6 (DPPX) produces altered behavior and hippocampal physiology
Megan McGill: Decreased amplitude of low frequency BOLD fluctuations in thalamic subregions of patients with idiopathic generalized epilepsy
Melissa McKenzie: A role for FGF signaling in interneuron development
Xiasong Meng: Evidence for a Necl-4, Par-3 and 4.1G Complex in Myelinating Schwann Cells
Frederick Tsai: FKBP12 binds to acylated H-Ras and promotes depalmitoylation
Danielle Zheng: Effect of food restriction on components of addiction
The Keynote Lecture "STAT3 in T cells: At the Crossroads of Inflammation and Cancer" was delivered by Assistant Professor of Pathology Sergei Koralov, PhD, who recently joined the NYU School of Medicine from Children's Hospital Boston and the Immune Disease Institute at Harvard Medical School where he was a Postdoctoral Fellow.
Apart from the opportunity to ski the trails of the Stratton Mountain Ski Resort, retreat attendees also had the opportunity to go on shopping trips to the outlet malls and to take advantage of the resort's amenities, including a full-service sports center with indoor pool, cardiovascular and weight equipment, indoor tennis courts, basketball courts, massage, and fitness classes.
View a portfolio of photos from the event.